MMAF sodium

产品编号 T16122Cas号 1799706-65-2

别名 Monomethylauristatin F sodium

MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.

MMAF sodium

产品编号 T16122别名 Monomethylauristatin F sodiumCas号 1799706-65-2

规格	价格	库存	数量
50 mg	¥ 1,990	10-14周
100 mg	¥ 2,820	10-14周

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产品介绍

生物活性

产品描述	MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.
体外活性	MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4].
别名	Monomethylauristatin F sodium

化学信息

分子量	754.966
分子式	C₃₉H₆₅N₅NaO₈
CAS No.	1799706-65-2

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 200 mg/mL (265.27 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3246 mL	6.6228 mL	13.2456 mL	66.2281 mL
5 mM	0.2649 mL	1.3246 mL	2.6491 mL	13.2456 mL
10 mM	0.1325 mL	0.6623 mL	1.3246 mL	6.6228 mL
20 mM	0.0662 mL	0.3311 mL	0.6623 mL	3.3114 mL
50 mM	0.0265 mL	0.1325 mL	0.2649 mL	1.3246 mL
100 mM	0.0132 mL	0.0662 mL	0.1325 mL	0.6623 mL